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Flexible dosing: Each bottle contains up to 20 doses (25

1. Indications and Usage for Sildenafil Oral Suspension

That suggested to us [and] it's reasonable to assume that this suspension is absorbed more quickly. In addition, the average levels of the medication in the bloodstream, at least during the first 30 minutes, was higher. So, our thought process that if you deliver it that way, as a spray under your tongue, it would be absorbed faster, came out. It's always nice when you have a hypothetical concept and then all of a sudden, you do it clinically, and then it's working. The data wasn't like, "Well..." No, it's pretty clear.

5.5 Hearing Loss

It starts getting absorbed in 5 minutes, and that is much faster than we see with Viagra. This transcription has been edited for clarity. Kaplan is a member of the medical advisory board for Aspargo Labs. Hezkue suspension is an oral sildenafil spray that can effectively treat erectile dysfunction. Fast absorption within 5 minutes compared to Viagra tablets. mg), 10 doses (50 mg), or 5 doses (100 mg).

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No pills required – easy-to-swallow liquid with mint flavour.

Sildenafil (Active Ingredient in Viagra)

Do you know a pill dosage that works for you or would you benefit from a flexible dosage? “When you’re choosing ED treatment think about what will suit your lifestyle the best. Not all treatments work on their first go. Combining ED medication with healthy lifestyle changes, having a health check with your GP and trying therapy for emotional or mental health causes can all improve your ED. Keep an open mind and we can help you find the most suitable treatment for you.” – Dr Sameer Sanghvi For more information on the possible side effects of Hezkue and correct use, please read the patient information leaflet.

Benefits :

Please let your GP know if you experience any side effects while using Hezkue. Like any treatment, you may experience side effects when taking Hezkue. Very common side effects (may affect more than 1 in 10 people) Common (may affect up to 1 in 10 people) Changes to sight (colour perception, blurred vision) Uncommon (may affect up to 1 in 100 people) Changes to heart rate and blood pressure Pain in upper abdomen, arms or legs Rare (may affect up to 1 in 1000 people) Changes to sight including spots in vision *Data based on mean plasma concentration after application of 8 pumps of HEZKUE®/BANDOL® (100 mg of sildenafil) compared to Viagra® tablets (100 mg sildenafil). Initial absorption of HEZKUE®/BANDOL® (100 mg of sildenafil) was observed within 5 minutes after administration (0.615 ng/mL, p = 0.012) vs Viagra® 100 mg tablets that showed no absorption at that time. It will be available other markets upon approval. Hezkue is a branded prescription-only oral sildenafil spray that is quickly absorbed

Substance/Class	Effect on Sildenafil Spray	Recommendation
Nitrates	Potent hypotensive effect	Avoid concomitant use
Alpha-blockers	Increased risk of low blood pressure	Use with caution, under supervision
Alcohol	Enhances side effects	Limit or avoid consumption
Other PDE5 inhibitors	Increased risk of adverse effects	Do not combine

into the bloodstream and can provide fast, effective relief from erectile dysfunction.

Dosage Level	Number of Sprays	Recommended Use Frequency	Precautions
Low	1-2 sprays	Once per day	Start with lowest dose; assess response
Moderate	3-4 sprays	Once or twice daily	Avoid alcohol to reduce side effects
High	5+ sprays	As prescribed by doctor	Not recommended without medical advice

The active ingredient, sildenafil, is the same as Viagra, but it is provided in an oral spray.

Can you use a Sildenafil Suspension and Sildenafil tablets at the same time?

Our initial product is a proprietary oral suspension formulation of sildenafil citrate, the active ingredient in VIAGRA® currently available in Spain as BANDOL® and available across all other geographies as HEZKUE®. Please visit our country specific websites below: Fast absorption after just 5 minutes compared to Viagra® tablets2* *Data based on mean plasma concentration after application of 8 pumps of HEZKUE®/BANDOL® (100 mg of sildenafil) compared to Viagra® tablets (100 mg sildenafil). Fast absorption after just 5 minutes compared to Viagra® tablets2* *Data based on mean plasma concentration after application of 8 pumps of HEZKUE®/BANDOL® (100 mg of sildenafil) compared to Viagra® tablets (100 mg sildenafil). With personalized dosing, HEZKUE®/BANDOL® is tailored to the users’ individual needs and lifestlyes and eliminates the need for planning.2 HEZKUE®/BANDOL® is bioequivalent to Viagra® tablets, offering a safe and effective alternative for treating ED.2 Delivers the same efficacious dose as Viagra®2* *Compared to Viagra® 100 mg tablets and well-established safety profile for sildenafil used in the treatment of ED. ** With respect to AUC, measured after application of 8 pumps of HEZKUE®/BANDOL® (100 mg of sildenafil) compared to Viagra® tablets (100 mg sildenafil).

Sprays vs. Pills

2024.1 #Data based on mean plasma concentration after application of 8 pumps of HEZKUE®/BANDOL® (100 mg of sildenafil) compared to Viagra® tablets (100 mg sildenafil). Initial absorption of HEZKUE®/BANDOL® (100 mg of sildenafil) was observed within 5 minutes after administration (0.615 ng/mL) while Viagra® 100 mg tablets showed no absorption at that time.1 Viagra® (sildenafil) is a drug marketed in Spain by Viatris Pharmaceuticals S.L.( Initial absorption of HEZKUE®/BANDOL® was observed within 5 minutes after administration while Viagra® tablets showed no absorption at that time.1 Prospective, open-label, single-centre, two-way crossover comparative bioavailability study in 56 healthy male volunteers in fasting conditions. HEZKUE®/BANDOL® is bioequivalentto sildenafil tablets*2 HEZKUE®/BANDOL® is a safe and effective alternative for ED2 *The Pharmacokinetic study showed that HEZKUE®/BANDOL® was found bioequivalent to Viagra® tablet with respect to sildenafil systemic exposure, as reflected in the 90% confidence intervals for AUClast and AUC∞. HEZKUE®/BANDOL® and Viagra® tablet were not bioequivalent with respect to Cmax, with a modestly higher maximum sildenafil concentration for HEZKUE®/BANDOL®.1 Anti-Anxiety Medications, Anti-Depressants & Sleeping Pills5 In young men, it is usually undervalued and attributed to psychological problems6 HEZKUE®/BANDOL® is a ready-to-use sildenafil suspension spray. See HEZKUE®/BANDOL® product information (as of May 2024). Hezkue works by increasing blood flow to your penis, so when you

Side Effects and Safety Considerations

This will not increase the chances of you getting an erection. It will, however, increase the risk of you suffering from the side effects of sildenafil (see below). If you've tried Hezkue at this dose on at least six separate occasions, and you haven't found it effective, our clinicians may advise increasing to the maximum dose. Do not exceed the maximum recommended dose. Doing so increases the risk of experiencing potential side effects.

Does sildenafil interact with foods or drinks?

Hezkue is suitable for adult men who suffer from erectile dysfunction. You are allergic to sildenafil (or any of the ingredients in Hezkue) You are allergic to sildenafil (or any of the ingredients in Hezkue) You are taking medicines like nitrates or Riociguat as this may affect how they work You are taking medicines like nitrates or Riociguat as this may affect how they work You have had severe issues with your heart or liver You have had severe issues with your heart or liver For more information on whether Hezkue may be suitable for you, contact our clinicians through your Account or read the patient information leaflet. As Hezkue provides the same dose as a Viagra tablet and contains the same active ingredient, there isn’t a significant difference between the two treatments other than how they are administered. But if you’re unsure whether you’d prefer a spray over a tablet, keep the following in mind: Are you comfortable with ED pills (both psychologically and if you have any troubles with swallowing) Are you comfortable with ED pills (both psychologically and if you have any troubles with swallowing) Are you more likely to remember to carry a pill or Suspension bottle? Are you more likely to remember to carry a pill or Suspension bottle? are sexually aroused, it is easier to get and maintain an erection.

Before Using

Study UNICO: Perception of Urologists and Andrologists, in Spain, about the Use of Sildenail Oral Suspension in Patients with Erectile Dysfunction. Opinions, Attitudes, and Perceptions in Relation to Erectile Dysfunction and Premature Ejaculation in the Undiagnosed Spanish Male Population. 2001;166(2):569-74. discussion 574-5. Rastrelli G, Maggi M.

Does Silfin Oral Spray affect sperm?

Erectile dysfunction in sildenafil 130mg fit and healthy young men: psychological or pathological? Aspargo Labs is in the process of bringing the most important Rx and OTC medicines to market as oral suspensions. Jesse Ory, MD Clinical Instructor and Urologist at the University of Miami “The nice thing with this is you can titrate up pretty easily without having to break up a bunch of pills and try and be your own pharmacist." "The problem is there’s so there hasn’t been anything new, really, in ED for at least 10, 20 years, ...truly new that that is being used by everyone...but guys are going out and just getting anything they can that is different.” Hossein Mirheydar, MDUrologist in Baldwin Park, California Kaiser Permanente “I think this product definitely looks like an exciting opportunity, in terms of the rapid onset of activity and also the utilization of a non-oral, GI-absorbing treatment. I would invite all my patients of all ages, to try an oral spray Sildenafil.” Dr. Laurence A. Studies show sildenafil sprays are as effective as tablets. And, previous trials have shown that 74% of people reported

Parameter	Value	Notes
Onset of Action	15-30 minutes	Faster than oral tablets
Peak Plasma Levels	30-45 minutes	Rapid absorption
Duration of Effect	Up to 4 hours	Similar to or slightly shorter than oral form

improvements in their erectile function with a 50mg dose tablet.

Warnings & Precautions

Levine, MDProfessor of Urology Department of Urology at Rush University Medical Center, Chicago “I think in general the concept of something oral … that you can just simply spray in your mouth really easily, and don’t have to worry about a pill and all the rest, I think is attractive.” “In addition, the average levels of the medication in the bloodstream, at least during the first 30 minutes, was higher,” says Steven A. Kaplan, MD. In this video, Steven A. Kaplan, MD, shares What we did in this study is to look at what happened in terms of pure absorption. So, these were patients who were given either 4 mL of the suspension vs 100 mg of sildenafil.

5.6 Combination with Other PDE-5 Inhibitors

What we found is that there was a faster absorption. I mean significantly faster absorption, which is what we hoped and what we thought. But it's kind of nice when you do the study and it actually happens. There was a higher average amount in the bloodstream compared to Viagra tablets. So, this is not generic, it's the Viagra tablets itself. If Hezkue sounds like a suitable ED treatment for you, you can request it directly from

• Sildenafil spray is approved in some regions for ED.
• It may provide a more convenient dosing method.
• Users should avoid driving until effects are known.
• The spray’s rapid absorption may enhance spontaneity.
• It is important to monitor blood pressure when using.
• Sildenafil spray should not be used with grapefruit juice.
• It’s essential to disclose all health conditions to the doctor.
• The spray formulation might reduce medication costs.
• It can be part of a healthy lifestyle for better results.
• Consistent application improves and prolongs effectiveness.
• Always consult healthcare providers before starting.

Superdrug Online Doctor by completing a short online questionnaire for one of our doctors to review.

• Sildenafil spray can enhance male sexual performance.
• It is often used when oral pills are not suitable.
• The spray allows for targeted delivery to the bloodstream.
• Rapid onset makes it suitable for spontaneous encounters.
• Use the spray exactly as directed by the healthcare professional.
• There is a risk of priapism with overuse.
• The spray may cause minor irritation at the application site.
• It is advisable to have medical supervision during use.
• The spray’s effectiveness depends on individual health.
• It is recommended to avoid alcohol for better results.
• Regular follow-up visits ensure safe use over time.