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Avanafil (brand-name Stendra) is a newer medication in the landscape of ED treatments. While other ED medications like sildenafil affect enzymes like PDE1 and PDE6 alongside PDE5, Stendra is more micro-targeted to inhibit the specific PDE5 enzyme related to a man’s ability to get and keep an erection. This increases Stendra’s efficacy while reducing its side effect profile.

• Tadalafil lasts longer than sildenafil, providing up to 36 hours of effect.
• Sildenafil was the first FDA-approved ED medication in 1998.
• Genérico versions offer a more affordable option.
• Warning signs include sudden vision loss or hearing decline.
• Combining with recreational drugs can cause dangerous side effects.
• Men with kidney or liver issues should consult a doctor first.
• Tablets should be stored in a cool, dry place away from children.
• Always check for possible drug interactions before use.

Here are some other benefits of Stendra:47 48 According to an early clinical trial of more than 500 men, close to 3 in 10 using the maximum dosage of Viagra report headaches.

In case of emergency/overdose

BlueChew's free trial still makes it the best starting place for men new to ED treatments. After that, you can use the low price of Hims’ 30, 90-, and 150-day supplies to stock up on vardenafil chews at a lower cost (as long as you plan to finish your supply before it expires). But men seeking smaller quantities for as-needed use should stick with BlueChew. Per-dose cost via Hims is cheaper than Viagra Can take it with or without meals Not as affordable as sildenafil or tadalafil Many men prefer to take an ED medication only when they need it rather than at the start of a day when they may or may not have sex. Understandably, these men also want that drug to take effect as quickly as possible and with the lowest chance of side effects. By contrast, just over 1 in 10 men using the 200mg Stendra (highest dosage) report headaches. Only about 13% of men using 200mg Stendra experience flushing of the face, compared to 20% of men using the maximum dosage of sildenafil. Heartburn, muscle and back pain, congestion, and vision changes are all less likely with Stendra.

Product	Dosage	Quantity + Bonus	Price
Kamagra Oral Jelly	100 mg	90 + 8 Sachets	303.56€ 289.10€	Buy
Priligy Generic Dapoxetine	60mg	120 + 10 Pills	341.26€ 325.01€	Buy
Cialis Original	20mg	4 Pills	41.99€ 39.99€	Buy
Kamagra Polo	100mg	20 Pills	83.56€ 79.58€	Buy
Super Kamagra	160 mg	12 Pills	101.10€ 96.29€	Buy
Cialis Generic	60mg	60 + 4 Pills	145.06€ 138.15€	Buy
Levitra Generic	40mg	90 + 6 Pills	234.73€ 223.55€	Buy
Viagra Super Active	100mg	360 + 30 Pills	470.93€ 448.50€	Buy
Tadalista Super Active	20mg	30 + 6 Pills	128.09€ 121.99€	Buy
Cialis Soft Tabs	20mg	90 + 6 Pills	216.71€ 206.39€	Buy
Kamagra Oral Jelly	100 mg	30 + 5 Sachets	136.20€ 129.71€	Buy
Viagra Original	100mg	12 Pills	72.54€ 69.09€	Buy
Kamagra Gold	50 mg	20 Pills	73.17€ 69.69€	Buy
Cialis Super Active	20mg	30 + 6 Pills	128.09€ 121.99€	Buy

Stendra also acts quicker in the body than others — some studies showed efficacy in as little as 15 minutes.15 This speed makes Stendra a great treatment choice for men who don’t always know when they’ll want to have sex and are happy to take something shortly beforehand.

How are oral ED drugs similar?

Many providers that stock generic sildenafil for ED prefer these 20mg tablets because they allow for more dose flexibility from a single stockpile of pills. A doctor can prescribe 20mg, 40mg, 60mg, or 100mg, and the patient simply takes the corresponding number of 20mg pills. Both branded and generic Viagra come in 25mg tablets, 50mg tablets, and 100mg tablets. If the most common dose is 50mg, then those 100mg doses are going to sit on the shelf, gradually approaching their expiration date and causing providers to lose money. Like tadalafil, sildenafil doses can vary to greater degrees, especially as delivery mechanisms change.

FYI on ED

For example, BlueChew’s chewable tablets come in 30mg and 45mg doses, neither of which exist in the typical dose ranges for pills. Here’s a quick visual reference detailing which versions of sildenafil our top choices offer: Our recommendation here, for most men, is generic sildenafil. Sildenafil is far more economical and allows for better dose tailoring. Rocket Rx has the best prices for sildenafil on the market, and it offers these prices without a major commitment. While low prices from Hims and Strut rely on lower doses or 5-12-month billing cycles, Rocket gets you low prices from orders containing up to 64 tablets.

Watch out for side effects

That means you stand to spend a lot less up front to find out if the medication and dose are a fit. For men new to ED medication who want to test the waters while spending as little as possible, BlueChew may be a good place to start, if only because the medication is super convenient to take and because the company offers a free trial. So you can try it out with very little financial risk. Hims also offers sildenafil in a chew, but only combined with another medication and only at a relatively high combination of doses (which we’ll discuss later in our combination therapy section). However, there are definitely situations in which you might want to opt for Hims’ sildenafil: Hims sildenafil is available in a wider number of doses, making it our top choice for men who find they need to fine-tune or maximize their dosage of sildenafil for the best effect or to reduce side effects. If this describes you, then we recommend Hims Stendra. Stendra is also our top choice for couples who enjoy morning sex.

Which ED drug should a man choose?

Hims telemedical support is fantastic for men who are dealing with ED alongside efforts to treat premature ejaculation. If you’re one of the many men who already use Hims for hair loss treatment or another service, then it could be convenient to use the same provider for ED treatment as well. Hims offers classic, brand-name Viagra or an authorized generic for men who want it. Hims is also the only company we recommend that sells an authorized generic Viagra. Interestingly, Roman lists their options as “Branded Viagra” and “Generic Viagra.” That second option is actually generic sildenafil — it is not an authorized generic made by Pfizer.

Sildenafil may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

Roman lists their sildenafil this way out of the belief that it makes it easier for potential patients to understand that the two drugs are practically identical. Visit our Roman review to learn more. Starts working in as little as 30 minutes Doesn’t cause a particular — but rare — side effect of sildenafil Available in chewable form from BlueChew and Hims While it isn’t the most widely available option from telemedicine providers, vardenafil is an important option for the few men who might not have success taking sildenafil but still want an effective medicine they can take on demand 30-60 minutes before sex. Studies show that vardenafil behaves the same way in the body as sildenafil, with one known exception. A rare medicine for erectile dysfunction side effect of sildenafil is an alteration in color perception due to the drug’s inhibition of PDE6 in addition to PDE5.13 Vardenafil is somewhat more selective in this regard, having no known effect on PDE6 and, therefore, no known effect on color perception.

Key takeaways

And while vardenafil is less thoroughly researched than sildenafil, there are still numerous studies looking at thousands of users over nearly two decades, so its safety and efficacy are without question.14 For a while, BlueChew was the only provider among our top picks to offer vardenafil, but Hims has included it in its recent development of chewable mint tablets. Despite not typically being a daily medication, Hims offers a 30-day supply of vardenafil that bears the same low price as its daily tadalafil. As a result, you can get 8.5mg vardenafil chews from Hims for significantly less than you can from BlueChew. Hims’ low price on vardenafil reflects their pricing for a 150-day supply. If you don’t want to stockpile vardenafil like that, the next-lowest price per dose you can get from Hims on smaller quantities of vardenafil is $6, which is more expensive than even the highest price per dose from BlueChew. Tadalafil taken in the morning can sometimes require about an hour before it is fully effective. This experience with tadalafil varies — some men find tadalafil to be effective for a full 36 hours (which would make the prior morning’s dose still effective), while others find its effects wear off in closer to 18 hours. If you are in the latter camp, Stendra will be better for your morning rituals because you can take a dose as you wake up and then be ready for fun in as little as 15 minutes.

• Tadalafil can be used for both erectile dysfunction and BPH.
• Sildenafil is the most studied and widely used ED medication.
• Some tablets are formulated for rapid onset within 15 minutes.
• The market offers various formulations: tablets, softgels, and dissolvables.
• Adjusting dosage may be necessary for optimal effectiveness.
• Men with hormonal imbalances might need additional therapy.
• Tablets should not be taken more than once within 24 hours.
• Be aware of potential interactions with antibiotics and antifungals.

However, Stendra will cost you significantly more than sildenafil or tadalafil.

• Physical activity increases nitric oxide levels aiding erections.
• Stress and anxiety are common causes of ED needing medication.
• Certain medications for other conditions may affect ED treatment.
• Some ED tablets require prescription based on health history.
• Age-related decline impacts the effectiveness of ED tablets.
• Combining multiple ED medications is not recommended.
• Men should discuss any ongoing health issues with their doctor.
• Proper hydration and sleep contribute to better erectile function.

Hims — our top choice for convenient access to Stendra — offers a monthly subscription for four 100mg Stendra tablets at $210 per month, billed quarterly.

• Natural alternatives include herbal supplements like ginseng and L-arginine.
• Psychological factors like stress can affect tablet effectiveness.
• Proper diet and exercise can improve erectile response over time.
• Avoid excessive alcohol consumption when taking these tablets.
• These medications do not increase sexual desire, only performance.
• Some tablets are available over-the-counter in certain regions.
• Always follow dosage instructions to minimize risks.
• Use caution if you have cardiovascular conditions.

If you can afford the cost, this may be the best choice for you. If not, then we’d suggest you explore daily tadalafil.

Brand Name	Active Ingredient	Onset of Action	Duration of Effect	Typical Price ($)
Viagra	Sildenafil	30-60 minutes	4-6 hours	20-30
Cialis	Tadalafil	30 minutes	Up to 36 hours	40-60
Levitra	Vardenafil	25-60 minutes	4-5 hours	25-45
Staxyn	Vardenafil ODT	15-20 minutes	4-5 hours	30-50

There are three standard dosage options for Stendra: Both the 100mg and 200mg dosages take effect in about 15 minutes. Sublingual dose requires no water to take FDA-approved for use in Parkinson’s patients May cause fainting in a small fraction of users Nausea is a common initial side effect Hard to find outside Rugiet’s blended ED treatment Apomorphine has been used since the 19th century as everything from a sedative to an aid in kicking heroin addiction, and it’s currently FDA-approved for treating Parkinson’s disease. However, multiple studies indicate its potential as a treatment for ED.16 The name can be a source of confusion since most people outside the medical professions would likely hear the “morphine” part and assume opioid properties. But apomorphine doesn’t bind to opioid receptors and is nonaddicting.

Buying oral erectile dysfunction medications online

Some men familiar with Viagra, having used it before successfully, want to stick with what works. They trust it, and the brain is the largest and most important sex organ after all; psychology can be a potent tool in combating ED. But a complete understanding of your options requires a little knowledge about the differences between Viagra, generic Viagra, and generic sildenafil. This is the original “little blue pill,” and it’s the most expensive option. Made by Pfizer, Viagra is available in 25mg, 50mg, and 100mg tablets from most providers.

Can you use baking soda for erectile dysfunction treatment?

We consider Roman the best choice for branded Viagra thanks to their low per-dose pricing compared to Hims ($90 vs. $138). This is a generic form of Viagra either made by Pfizer or by an authorized company with which Pfizer has shared their exact formula. It’s identical to branded Viagra in every way except that it won’t say “Viagra” on the prescription label. This is one of the least expensive options, though it’s often pricier than generic sildenafil.

Language matters

This is a formula therapeutically identical to branded Viagra but with discrepancies in inactive ingredients, color, shape, and delivery mechanism. Doses are theoretically supposed to be the same, but there are caveats. This is often the least expensive option. Sildenafil is also the active ingredient in Revatio, a drug designed to treat pulmonary arterial hypertension. The drugs are identical in almost every way — they’re even both made by Pfizer — but Revatio is made only in 20mg tablets. For Parkinson’s patients, apomorphine is delivered via subcutaneous injection at doses often higher than those used in ED treatment.