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They cited the need for further study, particularly into the drug's interaction with nitrates and its potential to cause fainting in less than 0.2% of trial participants. Today, apomorphine remains FDA-approved for Parkinson’s disease but is only prescribed for ED treatment as an off-label use. The only major providers we recommend that offer apomorphine in any form are Rugiet and BlueChew, but they typically combine apomorphine with tadalafil and sildenafil in a lozenge. That lozenge’s sublingual administration may decrease the time it takes to start working. It’s possible to get apomorphine-only lozenges from Rugiet, but they only come in the 3mg dose at a cost of $30 for six doses. If you’re looking for ED medications that aren’t technically PDE5 inhibitors (which sildenafil, tadalafil, and vardenafil all are), this may be a viable route.

How can we help you?

Rugiet was the first to offer multiple drugs in a single product with its lozenges, but Hims and Roman soon followed suit. And BlueChew’s recently developed Max and Gold products combine several ED therapies into a single chewable tablet. Let’s start with Rugiet since it kicked off the combination craze with its product, Rugiet Ready. The specific combinations available to you from Rugiet depend on the results of your doctor’s consultation, but here’s a look at their standard mixes: As you can imagine, combining these three medications theoretically increases the chances that they will work for you quickly and remain active in your system for up to 24-36 hours (as long as tadalafil is one of them). However, side effect risks may also increase as you combine medications.

The mental side of sex

The obvious downside to Rugiet is its cost. You can opt for larger shipments to reduce your cost per dose, and that can save you over 30%, but it results in significant up-front costs. For example, a monthly six-pack of medium strength Ready is $99. To get the best cost per dose, you can get 12 of those six-packs shipped to you quarterly for $799. That’s a lot of savings, but it’s likely cost-prohibitive for many men. We’ll discuss these combination offering in our next section, which is all about combination therapies. May improve outcomes in men resistant to monotherapies Can offer treatment outside of just PDE5 inhibitors May increase the risk of side effects Combination therapies are exactly what they sound like: some combination of commonly prescribed ED medications. Studies have shown that certain combinations can be more effective than a monotherapy on its own.23 As with monotherapies, the exact combination and dosing will be a matter for your physician to prescribe. Combination therapies have become more popular among the providers in this guide. Rugiet was the first to offer multiple drugs in a single product with its lozenges, but Hims and Roman soon followed suit. And BlueChew’s recently developed Max and Gold products combine several ED therapies into a single chewable tablet. Let’s start with Rugiet since it kicked off the combination craze with its product, Rugiet Ready. The specific combinations available to you from Rugiet depend on the results of your doctor’s consultation, but here’s a look at their standard mixes: As you can imagine, combining these three medications theoretically increases the chances that they will work for you quickly and remain active in your system for up to 24-36 hours (as long as tadalafil is one of them). However, side effect risks may also increase as you combine medications. The obvious downside to Rugiet is its cost.

Product	Dosage	Quantity + Bonus	Price
Cialis Soft Tabs	20mg	90 + 6 Pills	216.71€ 206.39€	Buy
Levitra Soft Tabs	20mg	30 + 2 Pills	99.17€ 94.45€	Buy
Kamagra 100 mg	100 mg	180 + 6 Pills	436.79€ 415.99€	Buy
Levitra Soft Tabs	20mg	10 Pills	52.27€ 49.78€	Buy
Viagra Original	100mg	22 + 2 Pills	120.71€ 114.96€	Buy
Tadalista Super Active	20mg	120 + 16 Pills	382.15€ 363.95€	Buy
Kamagra Oral Jelly	100mg	220 + 18 Sachets	662.24€ 630.70€	Buy
Viagra Generic	25mg	120 + 6 Pills	125.56€ 119.58€	Buy
Levitra Generic	20mg	10 Pills	31.49€ 29.99€	Buy
Cialis Black	80mg	360 + 20 Pills	639.78€ 609.31€	Buy
Cialis Professional	20mg	60 + 2 Pills	183.83€ 175.08€	Buy
Viagra Generic	200mg	60 + 4 Pills	125.19€ 119.23€	Buy
Cialis Super Active	20mg	180 + 20 Pills	521.59€ 496.75€	Buy
Levitra Generic	40mg	60 + 4 Pills	162.37€ 154.64€	Buy
Viagra Original	100mg	120 + 8 Pills	470.39€ 447.99€	Buy

You can opt for larger shipments to reduce your cost per dose, and that can save you over 30%, but it results in significant up-front costs. For example, a monthly six-pack of medium strength Ready is $99. To get the best cost per dose, you can get 12 of those six-packs shipped to you quarterly for $799. That’s a lot of savings, but it’s likely cost-prohibitive for many men. To learn more about Rugiet’s offering, check out our comprehensive review of their services. Rugiet has also expanded its catalog 10mg vardenafil online to include a daily tadalafil combined with DHEA to boost testosterone, but we don’t regard DHEA as a very good option for improving testosterone levels with an OTC treatment. You can also get a combination of tadalafil with either minoxidil or paroxetine to treat hair loss or premature ejaculation concurrently with ED, but both treatments have less tadalafil in them than comparables from Hims.

Side effects

To learn more about Rugiet’s offering, check out our comprehensive review of their services. Rugiet has also expanded its catalog 10mg vardenafil online to include a daily tadalafil combined with DHEA to boost testosterone, but we don’t regard DHEA as a very good option for improving testosterone levels with an OTC treatment. You can also get a combination of tadalafil with either minoxidil or paroxetine to treat hair loss or premature ejaculation concurrently with ED, but both treatments have less tadalafil in them than comparables from Hims. Hims has led the way in the chewable combination space since they introduced their Hard Mints and Sex Chews. Recently, the company has expanded these efforts to introduce several new combination treatments that combine common ED medications with ingredients to treat hair loss, premature ejaculation, and more.

Be physically active

Here’s a quick look at some of its simpler combination chewables: Hims also offers more novel combinations that slightly outperform those Rugiet recently added to its catalog. This product combines daily tadalafil (likely as a 2.5mg or 5mg dose) with an unspecified dose of fluoxetine, a prescription selective serotonin reuptake inhibitor (SSRI) that’s been studied for years in the context of premature ejaculation.26 Like Climax Control, this Sex Rx product uses daily tadalafil as its ED-fighting base, combined with oral finasteride and oral minoxidil. It’s unclear at this time if the medication can be delivered with just one of those two hair loss medications, but both have been shown to be very effective as oral treatments.27 Again, this drug combination starts with tadalafil, and Hims has combined it with atorvastatin, a statin designed to reduce your risk of certain cardiovascular events, like myocardial infarction.28 Then there’s Roman’s combination sex chew offering, called Sparks, which is only available as a combination of 22mg tadalafil and 55mg sildenafil for the constant rate of $12/dose. That 22mg tadalafil dose is much higher than we’d recommend for men new to ED medications. If you’re used to taking such a high dose, this might be a viable product, but there are superior options with more flexible dosing for lower prices from Hims. Hims has led the way in the chewable combination space since they introduced their Hard Mints and Sex Chews. Recently, the company has expanded these efforts to introduce several new combination treatments that combine common ED medications with ingredients to treat hair loss, premature ejaculation, and more. Here’s a quick look at some of its simpler combination chewables: Hims also offers more novel combinations that slightly outperform those Rugiet recently added to its catalog. This product combines daily tadalafil (likely as a 2.5mg or 5mg dose) with an unspecified dose of fluoxetine, a prescription selective serotonin reuptake inhibitor (SSRI) that’s been studied for years in the context of premature ejaculation.26 Like Climax Control, this Sex Rx product uses daily tadalafil as its ED-fighting base, combined with oral finasteride and oral minoxidil. It’s unclear at this time if the medication can be delivered with just one of those two hair loss medications, but both have been shown to be very effective as oral treatments.27 Again, this drug combination starts with tadalafil, and Hims has combined it with atorvastatin, a statin designed to reduce your risk of certain cardiovascular events, like myocardial infarction.28 Then there’s Roman’s combination sex chew offering, called Sparks, which is only available as a combination of 22mg tadalafil and 55mg sildenafil for the constant rate of $12/dose. That 22mg tadalafil dose is much higher than we’d recommend for men new to ED medications.

Interacting Drug/Class	Effect on ED Medication	Clinical Concern	Recommended Action
Nitrates	Potentiate hypotension	Risk of dangerous blood pressure drop	Avoid concurrent use
Alpha-blockers	Additive blood pressure lowering	Dizziness, fainting	Dose adjustment, monitoring
CYP3A4 inhibitors	Increase ED medication levels	Increased side effects	Dose reduction, careful monitoring
Grapefruit juice	Inhibits CYP3A4 enzyme	Raises drug plasma levels	Avoid consuming with ED meds

If you’re used to taking such a high dose, this might be a viable product, but there are superior options with more flexible dosing for lower prices from Hims.

Treatment Type	Method Description	Advantages	Limitations
Vacuum Erection Devices	Mechanical pumps to induce erection	Non-invasive, drug-free	Temporary effect, discomfort
Penile Implants	Surgical placement of prosthetic devices	Permanent solution	Surgery risks, cost
Pelvic Floor Exercises	Kegel exercises to strengthen pelvic muscles	Improves erectile function over time	Requires consistency
Counseling and Therapy	Psychological support for ED causes	Addresses underlying issues	Time-consuming, variable results

BlueChew Max combines tadalafil with either sildenafil or vardenafil, depending on your preference, making it a superior choice for men interested in putting those two together without adding apomorphine to the mix.

ED Treatment Options

That makes them less ideal for certain situations and climates than more durable chews from Hims or Roman. With up to 40% of ED cases proving to be psychological in origin, a large number of men can find relief through mental health care, whether that’s talk therapy, psychiatry, or a combination of the two.44 You can try to find an in-person therapist or psychiatrist, but the industry has largely moved online over the last several years, so we’ll focus this section on teletherapy resources for mental health that can help men address psychogenic ED. While Cerebral is a little more expensive than some excellent competitors, it offers plans for talk therapy, psychiatry (medication access), or both. That makes it a great place to start for men concerned with psychological issues leading to ED, as they can start with talk therapy and expand their care to include medication if it becomes necessary, without having to switch to another platform. Cerebral also works with several insurance companies, so there’s a good chance you’ll only have co-pays to worry about if you’re covered.

Care & Services

Here’s a current list of Cerebral’s insurance partners: Of course, coverage varies by state and by plan, so if your provider is on that list, it’s not a guarantee you’ll be covered. Still, those providers account for more than half the U.S. population, so it would be worth visiting the Cerebral site to check your coverage. And if you’re not insured, Cerebral still offers plans that are competitively priced and may still be affordable for you. Other companies offer financial assistance for patients who lack insurance, but the care provided might not be as comprehensive as Cerebral’s offering. BlueChew Gold expands in the opposite direction, combining the three medications seen in Rugiet Ready and adding oxytocin to the mix. Oral oxytocin boasts some evidence for improving female sexual desire, and its reputation as “the love hormone” implies that these effects could work just as well in men. But there’s not enough science backing this up just yet. That said, as we’ll discuss soon, mental health plays a big role in ED, and oxytocin has been shown to help in cases of anxiety and depression. So, it’s possible that the oxytocin in Gold is there to address potential psychiatric complications around ED, rather than physiological ones.46 Given the current state of available doses, we don’t recommend combination therapies to men who haven’t tried ED medications before.

Review Date 1/1/2025

BlueChew Max combines tadalafil with either sildenafil or vardenafil, depending on your preference, making it a superior choice for men interested in putting those two together without adding apomorphine to the mix. BlueChew Gold expands in the opposite direction, combining the three medications seen in Rugiet Ready and adding oxytocin to the mix. Oral oxytocin boasts some evidence for improving female sexual desire, and its reputation as “the love hormone” implies that these effects could work just as well in men. But there’s not enough science backing this up just yet. That said, as we’ll discuss soon, mental health plays a big role in ED, and oxytocin has been shown to help in cases of anxiety and depression.

Key takeaways

So, it’s possible that the oxytocin in Gold is there to address potential psychiatric complications around ED, rather than physiological ones.46 Given the current state of available doses, we don’t recommend combination therapies to men who haven’t tried ED medications before. If you discover that a monotherapy can work for you, there’s no reason to add another medication to the picture. If you’ve tried monotherapies and had poor or mixed results at various doses, a combination therapy might be the way to go. In that case, we’d recommend starting with Hims, where you can choose between numerous combinations at slightly better prices and more super p force online reasonable doses than you’ll find from Roman, BlueChew, or Rugiet. Our testing also confirmed that Rugiet lozenges are susceptible to high temperatures and may melt if left in a hot car or even outside on a hot enough day. If you discover that a monotherapy can work for you, there’s no reason to add another medication to the picture. If you’ve tried monotherapies and had poor or mixed results at various doses, a combination therapy might be the way to go. In that case, we’d recommend starting with Hims, where you can choose between numerous combinations at slightly better prices and more super p force online reasonable doses than you’ll find from Roman, BlueChew, or Rugiet.

Myth 2: ED medications provide instant and continuous results.

They cited the need for further study, particularly into the drug's interaction with nitrates and its potential to cause fainting in less than 0.2% of trial participants. Today, apomorphine remains FDA-approved for Parkinson’s disease but is only prescribed for ED treatment as an off-label use. The only major providers we recommend that offer apomorphine in any form are Rugiet and BlueChew, but they typically combine apomorphine with tadalafil and sildenafil in a lozenge. That lozenge’s sublingual administration may decrease the time it takes to start working. It’s possible to get apomorphine-only lozenges from Rugiet, but they only come in the 3mg dose at a cost of $30 for six doses.

3. Urethral suppository

If you’re looking for ED medications that aren’t technically PDE5 inhibitors (which sildenafil, tadalafil, and vardenafil all are), this may be a viable route. We’ll discuss these combination offering in our next section, which is all about combination therapies. May improve outcomes in men resistant to monotherapies Can offer treatment outside of just PDE5 inhibitors May increase the risk of side effects Combination therapies are exactly what they sound like: some combination of commonly prescribed ED medications. Studies have shown that certain combinations can be more effective than a monotherapy on its own.23 As with monotherapies, the exact combination and dosing will be a matter for your physician to prescribe. Combination therapies have become more popular among the providers in this guide. Our testing also confirmed that Rugiet lozenges are susceptible to high temperatures and may melt if left in a hot car or even outside on a hot enough day.

• Initial Hope: The introduction of Viagra was a monumental breakthrough.
• Quality of Life: Focus shifted from just procreation to sexual satisfaction.
• Mainstream Acceptance: ED became a recognized medical condition, not a joke.
• Research Funding: Increased investment in men's sexual health research.
• Holistic Approach: Treatment now considers psychological and physical factors.
• Patient Empowerment: Men are more proactive in seeking solutions.
• Ongoing Evolution: Continual improvement in treatments and access continues.

That makes them less ideal for certain situations and climates than more durable chews from Hims or Roman.

• Alprostadil works by relaxing blood vessels to increase blood flow.
• Udenafil is primarily used in Asian countries.
• Yohimbine's effects are less predictable than prescription meds.
• ED medications have been extensively studied for safety.
• Be aware of counterfeit ED drugs in unregulated markets.
• Some medications can cause a sudden decrease in blood pressure.
• Proper dosing is crucial; overuse can cause adverse effects.
• Men with uncontrolled high blood pressure should consult a doctor.
• Use ED medications only as prescribed by healthcare providers.
• Age-related decline can affect medication effectiveness.

With up to 40% of ED cases proving to be psychological in origin, a large number of men can find relief through mental health care, whether that’s talk therapy, psychiatry, or a combination of the two.44 You can try to find an in-person therapist or psychiatrist, but the industry has largely moved online over the last several years, so we’ll focus this section on teletherapy resources for mental health that can help men address psychogenic ED. While Cerebral is a little more expensive than some excellent competitors, it offers plans for talk therapy, psychiatry (medication access), or both.

Innovation	Description	Potential Benefits	Current Status
Soluble Film Formulations	Medications in dissolvable film strips	Faster onset, easier administration	In development
Combination Therapies	Using PDE5 inhibitors with other agents	Improved efficacy in refractory cases	Clinical trials ongoing
Gene Therapy	Experimental approach targeting underlying causes	Potential long-term cure	Early research stage
Nanoparticle Delivery Systems	Enhanced targeted drug delivery	Reduced side effects, increased effectiveness	Preclinical studies

That makes it a great place to start for men concerned with psychological issues leading to ED, as they can start with talk therapy and expand their care to include medication if it becomes necessary, without having to switch to another platform. Cerebral also works with several insurance companies, so there’s a good chance you’ll only have co-pays to worry about if you’re covered. Here’s a current list of Cerebral’s insurance partners: Of course, coverage varies by state and by plan, so if your provider is on that list, it’s not a guarantee you’ll be covered. Still, those providers account for more than half the U.S. population, so it would be worth visiting the Cerebral site to check your coverage. And if you’re not insured, Cerebral still offers plans that are competitively priced and may still be affordable for you. Other companies offer financial assistance for patients who lack insurance, but the care provided might not be as comprehensive as Cerebral’s offering. Because talk therapy is likely the best place for men concerned with psychogenic ED to start, BetterHelp is a close runner-up to Cerebral. It doesn’t offer psychiatric care, so you’d have to switch to another platform if you ultimately need psychiatric medication to address the mental health concerns that are contributing to your ED. That said, if talk therapy is enough to address the problem (perhaps in combination with a PDE5 inhibitor discussed elsewhere in this guide), BetterHelp offers what we feel is the best combination of cost and quality of care. Two of the most common root causes for psychogenic ED are anxiety and depression, which are among the most commonly treated issues in telehealth psychology and psychiatry. As a result, our breakdown of evaluation criteria for ED-related treatment largely followed the same standards set in our guide to finding the best online therapy, specifically looking at quality of care, cost, privacy, and platform. Related:The Best Online Therapy in 2026 Evaluating the potential quality of care you might get from one company to the next is nearly impossible, given the thousands of therapists and psychiatrists involved, their diverse backgrounds, and your unique needs.

Increase the Dose

However, there are certain standards we look for in each company’s approach to hiring clinicians that can tell us a lot about the standard of care you can expect. For example, all of Cerebral’s clinicians have either a master’s or doctoral degree from an accredited institution, and the company provides licensing information on each therapist’s biography page. BetterHelp has similar degree and licensing requirements, but its therapists also have to have a minimum of three years or 1,000 hours of practice under their belt.

What should I know before taking ED medications?

Because talk therapy is likely the best place for men concerned with psychogenic ED to start, BetterHelp is a close runner-up to Cerebral. It doesn’t offer psychiatric care, so you’d have to switch to another platform if you ultimately need psychiatric medication to address the mental health concerns that are contributing to your ED. That said, if talk therapy is enough to address the problem (perhaps in combination with a PDE5 inhibitor discussed elsewhere in this guide), BetterHelp offers what we feel is the best combination of cost and quality of care. Two of the most common root causes for psychogenic ED are anxiety and depression, which are among the most commonly treated issues in telehealth psychology and psychiatry. As a result, our breakdown of evaluation criteria for ED-related treatment largely followed the same standards set in our guide to finding the best online therapy, specifically looking at quality of care, cost, privacy, and platform.

FYI on ED

Related:The Best Online Therapy in 2026 Evaluating the potential quality of care you might get from one company to the next is nearly impossible, given the thousands of therapists and psychiatrists involved, their diverse backgrounds, and your unique needs. However, there are certain standards we look for in each company’s approach to hiring clinicians that can tell us a lot about the standard of care you can expect. For example, all of Cerebral’s clinicians have either a master’s or doctoral degree from an accredited institution, and the company provides licensing information on each therapist’s biography page. BetterHelp has similar degree and licensing requirements, but its therapists also have to have a minimum of three years or 1,000 hours of practice under their belt. Without that requirement, you might get a doctor with a high-level degree but limited experience actually dealing with patients. Without that requirement, you might get a doctor with a high-level degree but limited experience actually dealing with patients.